IndraLab

Statements

USP48 activates Neoplasm Metastasis. 5 / 5
| 5
reach
"Consequently, we proceeded to investigate the function of USP48 in promoting CRC metastasis in vivo.Our findings consistently demonstrate that knockdown of USP48 in CRC cells significantly suppresses tumor metastasis compared to control cells in liver and lung metastasis models of CRC."
38572092
reach
"Collectively, these findings suggest that USP48 enhances tumor metastasis largely by regulating HMGA2 in vitro and in vivo.3."
38572092
reach
"Blockade of the deubiquitinating enzyme USP48 degrades oncogenic HMGA2 and inhibits colorectal cancer invasion and metastasis."
38572092
reach
"Subsequent research revealed that USP48 promotes tumor progression, metastasis, and chemoresistance by inhibiting the degradation of cancer-related proteins such as MDM2, RelA, Gli1, Aurora B, and HMGA2."
39878157
reach
"Interestingly, we found that reconstitution of USP48 WT in endogenous USP48-deficient DLD1 cells significantly increased cell migration capacity as well as lung metastasis compared to the USP48 K258R mutant (Fig. 6L and M)."
38572092