IndraLab

Statements

IL15 activates IL15RA. 10 / 10
1 | 9
signor
"Interleukin-15 specificity and high affinity binding are conferred by the IL-5-specific but nonsignaling IL-15R alpha subunit, which is structurally similar (but not homologous) to the alpha receptor subunit of IL-2"
17709786
reach
"Despite shorter culture conditions of 16 hours, we observed that CD8+ T cells transfected with IL-15RA and treated with IL-15 demonstrate higher% viability in the presence of dexamethasone compared to similarly treated no RNA transfected cells (XREF_FIG)."
19180469
reach
"In contrast, the culture of F15R-Kit with IL-15 was associated with the appearance of IL-15Ralpha in the endosomal fractions (fractions 6 and 7), supporting the view that IL-15 induces the internaliza[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
12433361
reach
"The key distinctions between these two cytokines are (a) IL-15 exhibits an affinity for its private alpha receptor subunit that is 400-fold higher than that of IL-2 and (b) IL-15 primarily signals in trans, with monocytes or dendritic cells (DCs) presenting IL-15Ralpha to NK cells or T cells rather than the conventional cis activation mechanism favored by IL-2."
25493332
reach
"In addition, increased levels of IL-15 supported strong pStat5 induction by WT, but not IL-15Ralpha -/-, CD8 + activated T cells, indicating that high IL-15 does not overcome the loss of cis expressed IL-15Ralpha (XREF_FIG)."
21984699
reach
"IL-15 induces signaling by both cis- and trans-presentation of IL-15 and IL-15Ralpha to CD122 and gammac."
21984699
reach
"By contrast, IL-15 induced only minimal CD8 + T cell proliferation in IL-15Ralpha -/ - mice (XREF_FIG C)."
11602647
reach
"The coordinated upregulation of surface IL-15 and IL-15Ralpha during EAE supported the possible requirement of IL-15Ralpha for IL-15 elaboration."
26752157
reach
"Similarly, IL-15 also signals through a heterotrimeric receptor, consisting of the shared subunits (CD122 and the gamma c) and the unique high affinity receptor, IL-15Ralpha (CD215)."
31816491
reach
"In this study, T cells that specifically demonstrated high levels of IL-15RA expression were treated with IL-15 prior to transfer into leukemia bearing mice."
19180469