IndraLab

Statements

Gallic acid activates USP2. 3 / 3
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"As shown in Fig. 2E and F, compared with DMSO treatment, GA increased the thermal stability of USP2 in MM.1S cells; meanwhile, no significant change in the thermal stability of vinculin (negative control) could be observed."
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"We further revealed that the USP2 stabilizes KRAS by deubiquitination; consequently, USP2 inactivation induced by GA could lead to the destabilization of KRAS, resulting in the suppression of MM cell proliferation in vitro and in vivo."
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"In addition to the CETSA results, the drug affinity-responsive target stability assay showed that GA could prevent the pronase-mediated digestion of USP2 in a dose-dependent manner (Supporting Information Fig. S4)."
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