IndraLab

Statements

USP18 binds Interferon. 7 / 7
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"For instance, STAT2-dependent USP18 recruitment to the type I IFN receptor subunit IFNAR2 is required for USP18-mediated receptor dimerization interference [21, 23, 24]."
35320431
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"To exert its function as a negative regulator, USP18 binds to the IFN receptor/JAK complex and attenuates the magnitude of the response ( xref ; xref ; xref )."
33633774
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"Since we have shown that binding of Usp18 to type I IFN receptor subunit 2 (Ifnar2) is important for Usp18 mediated downregulation of type I IFN signalling, we investigated a potential interaction of Usp18 with the IFN-lambda specific receptor subunit IL-28R1."
23681607
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"USP18 is an inhibitor of IFN signaling xref , xref that is up regulated in chronic HCV infection, and lower levels of USP18 are associated with suppression of viral replication in vitro and a beneficial response to IFN in patients xref , xref ."
30510168
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"Interestingly, a high level of USP18 expression has been associated with non-response to IFN treatment ( xref )."
20633102
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"Baseline USP18 IFN -N levels are associated with both virological and serological response, and have the potential to become a clinical predictor for treatment outcomes in HBeAg-positive CHB patients before initiating IFN-α therapy."
31074081
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"Interestingly, USP18 in humans (but not in mice) can also interfere with the anti-viral outcome of IFN signaling by an additional mechanism: USP18 can bind the interferon receptor 2 (IFNAR2), block the association of JAK, and possibly limit IFNAR2-IFNAR1 dimerization, thereby interfering with the JAK-STAT signaling pathway [89]."
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