IndraLab

"Actual and potential interactions between cell receptor signaling pathways (receptor cross-talk) : interaction between TNF-alpha and the insulin receptor."

"Donnahoo et al. [9] have shown that I–R-induced renal TNF production was associated with impaired renal function and TNF-binding protein restored creatinine clearance."

"The HIRMAb-TNFR fusion protein binds both the HIR and TNFα with low nM affinity."

"Most recently, data have been presented from two Phase IIb studies, known as TASKi2 (MTX-IR) and TASKi3 (TNF-IR), which assessed syk kinase inhibition in the treatment of RA [85,86]."

"Actual and potential interactions between cell receptor signaling pathways (receptor cross-talk): interaction between TNF-α and the insulin receptor."

"CD44: Cluster of Differentiation 44;GSK: glycogen synthase kinase; ERK: extracellular signal-regulated kinase;RASP65: Golgi stacking protein;KRT18P55: Keratin 18 Pseudogene 55;bFGF: basic fibroblast growth factor; CAFs: cancer-associated fibroblasts;TSP-1: thrombospondin-1;S1P: Sphingosine-1-phosphate;MDSCs: myelogenic suppressor cells;IL-2: Interleukin-2;INF: interferon; TNF: Tumor Necrosis Factor:Insulin Receptor Substrate 1;EY cells: Human Embryonic Kidney cells; ARG: arctigenin; PDCD4:the tumor-suppressant gene programed cell death factor-4;ABCA3:ATP-Binding Cassette Subfamily A Member 3;PPP: pentose phosphate pathway;G6PD:Glucose-6-Phosphate Dehydrogenase;PFK: Phosphofructokinase;PKM2: Pyruvate Kinase M2;TKT: Pyruvate Kinase M2;ROS: reactive oxygen species; Cyt C:Cytochrome C;STAT3: Signal Transducer and Activator of Transcription 3;McL-1:Myeloid Cell Leukemia Sequence 1;Bcl-xl: B-cell Lymphoma-extra Large;Bcl-2: B-cell Lymphoma 2; TME: tumor microenvironment; CD4+/CD8+: cluster of differentiation 4 receptors/cluster of differentiation 8 receptors; DDP: Delivered Duty Paid; IGFR1R: insulin-like growth factor 1 recepto; IGF2: insulin-like growth factor 2; IRS1: insulin receptor substrate-1; bFGF: basic fibroblast growth factor; IC50: half-maximal inhibitory concentration; PAFR: platelet-derived growth factor receptors; EGFR: epithelial growth factor receptor."

"One scenario could be a direct interaction of TNF -α affecting the insulin receptor [ xref , xref , xref , xref ]."