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KCNK2 inhibits cell population proliferation. 9 / 12
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"KCNK2 siRNA for 48 h also suppressed the facilitated proliferation (11.6 ± 2.0% decrease, n = 19, p = 0.013 vs. control siRNA, n = 19) (Figure 7B)."
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"Furthermore, TREK-1 inhibits proliferation of neuronal stem cells, astrocytes, osteoblasts, Chinese hamster ovary cells, and neonatal cardiomyocytes, but increases the proliferation of prostate cancer cell lines."
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"Bupivacaine and curcumin, two strong TREK-1 channel inhibitors, significantly increased embryonic NSC viability and proliferation while transfection of hTREK-1 decreased cell proliferation in embryonic NSCs."
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"Over-expressed human TREK-1 inhibits CHO cell proliferation via inhibiting PKA and p38 MAPK pathways and subsequently inducing G1 arrest."
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"TREK-1 overexpression suppresses CHO cell proliferation by inhibiting the activity of PKA and p38 and MAPK signaling pathways and subsequently inducing G1 phase cell arrest."
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"BL1249, a K2P2.1(TREK1) activator, was able to inhibit the proliferation and migration of the human PDAC cell line BxPC-3 cells (91)."
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"However, other studies have shown that TREK-1 can inhibit the proliferation of cardiomyocytes (Yang et al., 2014)."
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"The TREK-1 blocker curcumin reduced proliferation by 44% at 120 hrs at the highest concentration tested (XREF_FIG D), whereas L-methionine (XREF_FIG A) and L-methioninol, blockers of stretch dependent channels thought to be TREK-1, showed no effect (P> 0.05) on proliferation."
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"Moreover, blockages of TREK-1 by bupivacaine have been demonstrated to upregulate bone cell proliferation."
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