IndraLab

Statements

NS1643 inhibits KCNH2. 4 / 4
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"NS1643 and NS3623 primarily reduce the inactivation of hERG by shifting its voltage dependence rightward [115,118]; neither compound was designed to interact with the S5-pore linker and their sites of action with the hERG channel are as yet unknown."
17298291
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"12 Surprisingly, results from the present study demonstrate that prolonged stimulation of hERG1 channel in the ER negative breast cancer SKBr3 cells treated with NS1643 arrested the cells in the G0/G1 phase."
23744352
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"NS1643 reduces the rectification of hERG through fast channel inactivation, thus slowing the onset of hERG inactivation."
23840331
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"Binding of NS1643 to the central cavity site appears to mediate pharmacologic block of hERG1 XREF_BIBR."
25191697