IndraLab

Statements

TCF4 decreases the amount of SCN10A. 3 / 3
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"Together these results robustly validate our iTRAP method and suggest that under normal conditions, TCF4 represses the expression of KCNQ1 and SCN10a in layer 2/3 neurons of the rat prefrontal cortex."
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"TCF4 loss-of-function leads to ectopic overexpression of Scn10a, and the pharmacological inhibition of NaV1.8 in murine models of PTHS is effective for the restoration of several physiological functions and behavior (Ekins et al., 2020; Cleary et al., 2021; Martinowich et al., 2022)."
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"that intact Tcf4 represses expression of SCN10a and KCNQ1 genes, in central neurons."
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