IndraLab

Statements

USP7 activates Melanoma. 5 / 5
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"8 , 12 Our group has also demonstrated that USP7 inhibition suppresses melanoma cell proliferation, migration, and invasion."
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"Suppression of USP7 expression can inhibit the growth and metastasis of melanoma cells both in vitro and in vivo [33]."
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"These data demonstrate that USP7-RRM2 interaction occurs predominantly in S phase and suggest a new role for USP7 in regulating cell cycle progression by modulating RRM2 protein levels throughout S ph[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Pharmacological inhibition of USP7 suppresses growth and metastasis of melanoma cells in vitro and in vivo."
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"Selective USP7 inhibition synergizes with MEK1/2 inhibitor to enhance immune responses and potentiate anti-PD-1 therapy in NRAS mutant melanoma."
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