IndraLab

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"Ablation of myosin-IIB in mice is embryonic lethal, and myosin-IIB ( MYH10 ) mutations are thought to be embryonic lethal in humans, as well; however, myosin-IIB function has been associated with the pathogenesis of spinocerebellar ataxia type 6 (SCA6) through associations of myosin-IIB and Cav2.1 calcium channel polyglutamate tracts [ xref ]."