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USP2 inhibits PPARG. 2 / 2

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"Taken together, these results revealed a previously unrecognized yet critical role of USP2 in the regulation of PPAR-γ signaling and in the pathogenesis of muscle atrophy.Our mechanistic investigations revealed that USP2 prevents muscle atrophy by regulating the stability of PPAR-γ, a key TF implicated in muscle metabolism and insulin sensitivity (31–33)."

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"Therefore, we hypothesized that Usp2 depletion in the diabetes- and DEX-induced muscle atrophy models might destabilize PPAR-γ protein."

39874418

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IndraLab

Statements

USP2 inhibits PPARG. 2 / 2

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