IndraLab

Statements

Calcitriol inhibits STAT1. 4 / 4
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"Thus, strategies that ameliorate HGPS cellular phenotypes mimic the effect of calcitriol, reducing RS and repressing the STAT1 pathway, though calcitriol 's effect is the most robust."
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"In turn, inhibition of STAT1 by calcitriol was demonstrated to improve the phenotypes of HGPS cells [ xref ]."
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"We previously demonstrated the ability of calcitriol to decrease STAT1 tyrosine 701 (p-STAT1) and STAT3 tyrosine 705 (p-STAT3) phosphorylation as well as inflammatory cytokine output of T cell large granular lymphocyte leukemia cells, but did not determine the effects of calcitriol on NK-LGLL."
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"In turn, inhibition of STAT1 by calcitriol was demonstrated to improve the phenotypes of HGPS cells [153]."
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