IndraLab

Statements

TGFBR1 phosphorylates OTUB1. 4 / 4
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sparser
"SB505124, a selective inhibitor of TGFβ-acitvated ALKs, inhibited the phosphorylation of OTUB1 by ALK5 in a dose-dependent manner ( xref )."
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"Both OTUB1 and OTUB1[S16A] were robustly phosphorylated by ALK5 ( xref ), suggesting that Ser 16 was not a major ALK5 phosphorylation site."
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"ALK2 through ALK6 all phosphorylated OTUB1 in vitro; however the TGFβ-activated ALK4 and ALK5 phosphorylated OTUB1 more robustly than the BMP-activated ALK2, ALK3 and ALK6 ( xref )."
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"In contrast, OTUB1[S18A] was poorly phosphorylated by ALK5, whereas OTUB1[S16A/S18A] was not phosphorylated ( xref ), suggesting that Ser 18 is the main ALK5 phosphorylation site on OTUB1."
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