IndraLab

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OTUD3 activates OTUD3. 4 / 4
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"Taken together, these results demonstrated that OTUDin3 inhibited lung cancer cell growth, migration and invasion, and induced apoptosis by targeting OTUD3."
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"OTUD3 promotes CCA proliferation and metastasis in vivo and in vitro by interacting with ARID3A.GSK3β interacts with OTUD3 protein and mediates phosphorylation of the Ser9 site of OTUD3, which enhances the affinity of OTUD3 to ARID3A and further stabilizes ARID3A protein."
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"For example, the acetyltransferase CBP promotes OTUD3 acetylation for its nuclear translocation, allowing OTUD3 to deubiquitinate and stabilize the intranuclear metabolism-associated transcription factor PPARδ thereby affecting gene expression related to glycolipid metabolism and oxidative phosphorylation (OXPHOS) (Zhou et al., 2022) (Figure 3B)."
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"OTUDin3 inhibits NSCLC cell growth, migration and invasion, and induces apoptosis by targeting OTUD3."
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