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USP18 activates IFN-I. 2 / 2

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"Among the DUBs that interact with STING, five members, namely CYLD, OTUD5, USP18 (also termed UBP43), USP20, and USP44, have been demonstrated to promote IFN-I production and antiviral responses."

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"In addition, USP18 can recruit the deubiquitinase USP20 to deconjugate the ubiquitination of STING and enhance the stability of STING and the induction of IFN-I and inflammatory cytokines during DNA virus infection [96]."

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USP18 activates IFN-I. 2 / 2

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