IndraLab

Statements

USP46 activates Neoplasms. 7 / 7
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"However, in esophageal squamous cell carcinoma and cervical cancer (CC), USP46 increases tumor growth."
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"These results reveal the tumor-promoting activity of USP46 in melanoma is mainly through deubiquitinating and stabilizing NRAS Q61R/K mutants."
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"Our studies illustrated that USP46 could strikingly promote cell migration, invasion and tumor metastasis of ESCC."
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"Moreover, tumorigenicity assays showed that compared to cells overexpressing USP46, restoring YAP1 expression in cells overexpressing USP46 promoted tumor growth ( Fig. 4 F and G)."
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"In contrast, a different study showed that USP46 promotes proliferation and tumor growth of HPV-transformed cancers [ 27 ]."
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"These results implicated that USP46 promotes ESCC tumor metastasis in a catalytic-dependent way."
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"In addition to affecting the proliferation of cancer cells, USP46 has also been demonstrated to promote tumor metastasis by stabilizing ENO1 in human esophageal squamous cell carcinoma [ 28 ]."
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