IndraLab

Statements

OTUD4 increases the amount of KRT1. 4 / 4
| 4
reach
"Moreover, OTUD4 (1-425aa) enhanced the protein level of K-RTA and the transcriptional activity of K-RTA, similar to the effects of WT OTUD4 (Figs 6H and S6D)."
38215174
reach
"To dissect how OTUD4 enhances K-RTA expression, we knocked down OTUD4 and then treated the cells with MG132 to block proteasomal degradation or Bafilomycin A1 to block lysosomal degradation."
38215174
reach
"Since K-RTA plays a crucial role in KSHV reactivation and OTUD4 interacts with K-RTA, we hypothesized that OTUD4 may modulate K-RTA protein level to promote lytic reactivation."
38215174
reach
"These data suggest that OTUD4 enhances K-RTA protein level by modulating the proteasomal degradation pathway."
38215174