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A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

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INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

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UCHL3 inhibits CUL1. 4 / 4

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"We reveal that UCHL3 can inhibit Cullin1 neddylation in cells dependently on COPS5."

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"We found that overexpression of increased amounts of UCHL3 gradually inhibited endogenous Cullin1 neddylation, indicating that cellular Cullin1 neddylation are regulated by UCHL3 levels."

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"Our results showed that UCHL3 overexpression inhibits Cullin1 neddylation."

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"We find that in cells UCHL3 can decrease neddylation of Cullin1."

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UCHL3 inhibits CUL1. 4 / 4

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