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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TNFAIP3 inhibits TLR3. 2 / 2

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"A20 can inhibit TLR3 signals and can bind TRAF6, Nef-associated kinase/TANK-binding kinase 1, and IκB kinase ε ( xref – xref )."

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"41 In addition , A20 interacts with TRIF and inhibits TLR3 - and Sendai virus-induced activation of IFN-sensitive response element and IFN-beta promoter , suggesting that A20 is a virus-inducible protein that blocks both inflammatory and cellular antiviral responses ."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...