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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

ATXN3 inhibits TP53BP1. 2 / 2

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"Consistent with defective DSB induced ubiquitylation, we found that depletion of ataxin-3 also significantly reduced both BRCA1 (Fig XREF_FIG D) and 53BP1 accumulation (Fig XREF_FIG E) to laser inflicted DNA damage, as well as to ionizing radiation induced foci (XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY)."

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"Indeed, we found that over-expression of ataxin-3 in control cells already significantly reduced accrual of 53BP1 (XREF_SUPPLEMENTARY)."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...