IndraLab

Statements


USP22 activates MSH3. 5 / 5
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"3.5 USP22 activates the AKT and MRP1 pathway depending on SIRT1 in HCC cells."

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"XREF_FIG A, knockdown of USP22 by shRNA inhibited the AKT and MRP1 pathway compared with control shRNA cells and wild-type cells."

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"Similarly, overexpression of USP22 in BEL/7402 cells activated the AKT and MRP1 pathway."

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"Simply put, USP22 may activate the SIRT1–AKT–MRP1 pathway and consequently promote MDR in human HCC cells (226)."

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"Both of these findings indicated that USP22 upregulated MRP1 depending on the AKT pathway."