IndraLab

Statements

PRPF8 binds SHOX. 4 / 4
| 4
reach
"Prp8 then binds to the 3′SS while retaining interaction with the 5′-exon for exon ligation."
30395327
reach
"Our results show that Prp8 directly binds over the 5′SS and the BS during the first catalytic step, and over the 5′SS and 3′SS during the second step."
30395327
reach
"For pre-mRNA transcripts, PRPF8 preferentially bound to the 5’SS of pre-mRNA transcripts, consistent with previous work , but weak 5’SS were more affected by the PRPF8 p.H2309P mutation in retinal cells."
38605034
reach
"Interestingly, changes in PRPF8 binding to the affected exons with weak 5’SS were sequence-dependent (i.e., downregulated exons were cytidine-rich and upregulated exons were thymidine-rich)."
38605034