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Dioscin inhibits NLRP3. 18 / 18
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"Strikingly, Dioscin can inhibit NLRP3 activation."
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"Meanwhile, dioscin dramatically suppressed NLRP3 inflammasome activation."
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"The underlying molecular mechanism may be that dioscin reduces inflammation by reducing the production of pro-inflammatory cytokines and inhibiting the activation of inflammasome NLRP3 and Toll-like receptor 4 (TLR 4)/NF-κB signaling pathway [80]."
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"However, NLRP3 could also be inhibited by glyburide, dioscin, metformin and resveratrol, preventing the bone loss from the progress of pyroptosis."
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"Moreover, dioscin also can reduce the production of proinflammatory factors such as interleukin-1 beta (IL-1beta) and inhibit the activation of NLRP3 inflammasome in LPS induced mice mastitis."
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"Thus, Dioscin could relieve periodontal inflammation partly by inhibiting NLRP3 inflammasome."
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"In vitro experiments, the results showed that dioscin inhibited the inflammatory response and the activation of NLRP3 inflammasome, but the survival rate of mouse mammary epithelial cells (mMECs) induced by LPS+ATP is increased."
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"In brief, all the findings indicated that dioscin suppressed the P2X7R/NLRP3 inflammasome signals in diabetes cognitive dysfunction.Since dioscin presented a neuroprotective effect on diabetes cogniti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Dioscin, a natural steroid saponin, has been shown to inhibit NLRP3 inflammasome."
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"Western blotting results suggested that dioscin inhibited the activation of NLRP3 through down-regulating the protein expressions of NLRP3, apoptosis associated speck like protein containing a caspase recruitment domain (ASC), cleaved-caspase-1, as well as IL-1beta."
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"Therefore, these results insinuate that Dioscin may act as an inhibitor of the NLRP3 inflammasome.However, the potential pathways by which Dioscin restricts the assembly of NLRP3 inflammasome remain to be elucidated."
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"Dioscin inhibited NF-κB and NLRP3 inflammasome in NZB/W F1 mice."
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"A recent study further revealed that Dioscin can inhibit the activation of NLRP3 inflammasome [13] ."
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"On the contrary, Dioscin was capable to inhibit the priming and activation of NLRP3 inflammasome ( Fig. 7 B&C)."
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"It was reported that dioscin inhibited the activation and expression of NLRP3 in gouty arthritis (GA) [35] ."
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"Our research unveiled that dioscin suppressed the P2X7R and NLRP3 inflammasome signals in diabetes cognitive dysfunction."
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"Hence, it is speculated that Dioscin could inhibit NLRP3 inflammasome by governing both priming and activation processes.The protective effect of Dioscin against inflammation was explored by detecting the mRNA and protein expression of pro-inflammatory cytokines."
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"Dioscin Reduces LPS+ATP-Induced Activation of NF-kappaB Signaling Pathway and NLRP3 Inflammasome in mMECs."
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