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"These in vitro and in vivo data synergistically demonstrate that OTUB2 enhances ischemic stroke injury by potentiating neuronal necroptosis through RIPK3.Since OTUB2 promoted neuronal necroptosis and genetic deletion of OTUB2 ameliorated ischemic stroke injury, we further investigated whether inhibition of OTUB2 with inhibitors could protect mice from ischemic stroke."