IndraLab

Statements

TBMS-1 decreases the amount of STAMBPL1. 5 / 5
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"However, TBMS-1 significantly downregulated the expression of STAMBPL1, a DUB of c-FLIP, but had no effect on other DUBs (USP2, USP8, and USP9x) (Figure 4A)."
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"Additionally, TBMS-1 treatment downregulated c-FLIP and STAMBPL1 expression in HeLa and A549 cells; however, such effects were absent in normal EA.hy926 cells (Figure 4B)."
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"Interestingly, the results of this study showed that TBMS-1 only downregulates STAMBPL1 expression (Figure 4A,B)."
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"These findings were further confirmed in vivo using a xenograft model based on the observation that combined treatment with TBMS-1 and TRAIL decreased tumor volume and downregulated STAMBPL1 and c-FLIP expression levels."
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"Importantly, the combination of TBMS-1 and TRAIL therapy reduced the tumor volume and downregulated the expression levels of STAMBPL1 and c-FLIP in an in vivo xenograft model."
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