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USP14 deubiquitinates BECN1. 4 / 4
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"The DUB ubiquitin-specific protease 14 (USP14) could deubiquitinate BECN1 to enhance autophagy-dependent ferroptosis in A549 lung cancer cells [104]."
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"<span class="match term0">USP14</span> regulates autophagy by suppressing K63 ubiquitination of <span class="match term1">BECLIN 1</span>"
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"Based on these previous findings, we hypothesized that the suppression of Beclin 1 ubiquitination by USP14 might be critically associated with TRAF6 mediated ubiquitination in both autophagy and TLR4 mediated signaling."
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"The deubiquitination of BECLIN 1 by USP14 inhibits the PtdIns3P production of VPS34."
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