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TNF increases the amount of PLAUR. 14 / 14
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"Therefore, the effects of dicentrine on TNF-α-induced expression of MT1-MMP, uPAR, ICAM-1, and Cox-2 in A549 cells were detected by the western blot analysis."
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"Consistent with well-established effects, macrophages stimulated by TNF induced MMP9 , IL1B, and PLAUR expression while IL-4 stimulation increased expression of CCL23 , MRC1 , and LIPA (Fig.  xref c)."
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"The expression and cleavage of uPAR is upregulated by TNFalpha, interleukin 1beta (IL-1beta), and IL-6 [XREF_BIBR]."
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"We did not exhaustively explore this possibility, but did examine some likely candidates : VEGF, which signals through VEGF receptors to increase MT1-MMP expression XREF_BIBR; HGF, shown to induce MT1-MMP, MMP2, uPA, and uPAR expression in cancer cells XREF_BIBR, XREF_BIBR; and TNFalpha, which enhances uPAR expression by ECs XREF_BIBR."
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"Pro inflammatory cytokines, IFN-gamma) and TNF-alpha (not shown), as well as LPS) enhanced uPAR expression."
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"UPAR biosynthesis, the uPAR mRNA level and gene transcription are also increased by transforming growth factor beta (TGFss) and dexamethasone in A549 lung carcinoma cells [12], but reports of transcri[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"While TNFalpha enhanced uPAR gene expression after 24 hours of treatment (twofold increase), it strongly decreased uPA gene expression (more than 70% reduction) compared with nontreated control conditions."
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"Amiloride (1 mM) also markedly inhibited the uPAR mRNA expression induced by CHX and TNFa."
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"Since TNFalpha potently induces uPAR expression in cultured hepatic stellate cells [XREF_BIBR], it is interesting to know how hCLS formation induces TGFbeta activation during the development of NASH and how EPA suppresses the process."
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"Although tumor necrosis factor alpha (TNF) upregulated monocyte uPAR expression, anti-TNF did not influence the endotoxin induced increase in monocyte uPAR expression."
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"As shown in xref A,B, dicentrine at 10–20 μM significantly decreased the enhancement of TNF-α-induced MT1-MMP, uPAR, and COX-2 expression."
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"To characterize the signal transduction pathways which regulate the uPAR gene, further experiments are currently in progress to study the signalling pathways and the regulatory sequence (s) and transa[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"TNF-alpha for example is known to play an important role in cerebral malaria and enhances uPAR expression in macrophage like U937 cells, colon carcinoma cell lines, and endothelial cells (Van Hinsberg[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"To investigate whether induction of uPAR gene expression by TNFa or PMA was dependent on de novo protein synthesis, 139 1 2 3 4 - uPAR - -18 S rRNA- 12 3 4 5 Fig. 1."
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