IndraLab

Statements

IL6 inhibits KCNH2. 9 / 9
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"Interleukin-6 inhibition of hERG underlies riskfor acquired long QT in cardiac and systemic inflammation."
| DOI
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"Previous studies have found that IL-6 can directly block hERG channels in ventricular myocytes and over-activate the sympathetic nervous system [65,66]."
36135437
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"Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation."
30521586
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"IL-6 receptors and the Janus kinase (JAK) pathways mediated the inhibition of hERG induced by IL-6."
35087712
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"IL-6 directly blocks the human ether-à-go-go-related gene (hERG) potassium ion channel, with the consequent prolongation of action potential duration and delay in phase 3 of repolarization, causing QTc prolongation and risk of TdP development (3,4)."
34223287
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"Aromolaran AS, Srivastava U, Alí A, et al. Interleukin-6 inhibition of hERG underlies risk for acquired long QT in cardiac and systemic inflammation."
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"Indeed, IL-6 inhibits hERG and prolongs ventricular action potential duration."
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"Indeed , IL-6 inhibits hERG and prolongs ventricular action potential duration ( 101 ) ."
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"The consequences of pharmacological blockade of hERG may be exacerbated in hyperinflammatory states, since interleukin-6 can inhibit IKr/hERG via the Janus Kinase pathway (38) and the risk of arrhythmia may increase with severity of infection/inflammation (27)."
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