IndraLab

Statements

USP30 inhibits mitophagy. 9 / 9
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"The depletion of USP30 increases both pexophagy and mitophagy ."
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"Inhibition of USP30 results in mitophagy and cellular clearance ."
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"Based on its influence on mitophagy , USP30 inhibitors have been developed to promote mitophagy as a potential therapeutic option for PD227 ,228 ."
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"In contrast , USP30 inhibits mitophagy by opposing parkin-mediated ubiquitination of target proteins ."
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"Furthermore , the knockdown of USP30 enhances mitophagy in cultured cells21 ."
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"Depletion of USP30 has been shown to promote mitochondrial elongation and mitophagy ( Nakamura & Hirose , 2008 ) ."
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"Much less understood are the inhibitors of USP30 and whether inhibiting USP30 will activate mitophagy in vivo ."
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"Interestingly , recent studies have provided a comprehensive analysis of the impact of USP30 on mitochondrial ubiquitylation dynamics , establishing a model proposing that USP30 loss or inhibition may boost mitophagy by lowering the threshold of mitochondrial damage19 ,29,48 ."
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"Importantly , USP30 inhibition enhanced ubiquitin phosphorylation and mitophagy even in the absence of Parkin , placing USP30 upstream of Parkin ."
| PMC