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UCHL1 activates CDKN1B. 5 / 5
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"However, the failure of UCH-L1 over-expression to induce a G 1 arrest in cultured podocytes despite increased total p27 Kip1 levels and hypertrophy argue against the established role of nuclear p27 Ki[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Our results suggest that increased nuclear export of p27 Kip1 could be one mechanism of UCH-L1 dependent cytoplasmic p27 Kip1 accumulation in podocytes and that molecules other than JAB-1 might be imp[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Cytoplasmic p27 Kip1 levels increased significantly in PHN glomeruli and UCH-L1 inhibition significantly reduced the cytoplasmic p27 Kip1 accumulation in PHN glomeruli ( Fig. 5 D, left panel)."
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"Therefore, UCH-L1 induced p27 Kip1 cytoplasmic accumulation in podocytes independently of JAB-1 associated nuclear export.Nuclear export of p27 Kip1 is in part mediated by binding of p27 Kip1 to JAB-1[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Therefore, UCH-L1 induced p27 Kip1 cytoplasmic accumulation in podocytes independently of JAB-1 associated nuclear export.Since nuclear export of p27 Kip1 was increased by UCH-L1 over-expression, we a[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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