IndraLab

Statements

BAP1 activates JUN. 4 / 4
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reach
"RNA sequencing analyses revealed that reduced BAP1 expression suppressed ASXL1 Y591X -induced upregulation of the transcription factors activator protein 1 ( AP-1 ) and early growth response 1/2 ( EGR[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
34186160
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"All of these results further confirmed that BAP1 suppressed ICC cell proliferation, cell cycle progression, and invasion via inhibiting ERK1/2 and JNK/c-Jun signaling pathways."
30305612
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"Furthermore, we also demonstrated that hyperactivity of ERK1/2 and JNK/c-Jun signaling induced by BAP1 downregulation was necessary for ICC cell proliferation, cell cycle progression, and invasion in vitro and in vivo using the inhibitors of the ERK1/2 pathway (U0126) and JNK/c-Jun pathway (SP600125)."
30305612
reach
"These data clearly suggested that hyperactivity of ERK1/2 and JNK/c-Jun signaling induced by BAP1 downregulation is necessary for ICC cell proliferation, cell cycle progression, and invasion."
30305612