IndraLab
Statements
reach
"Furthermore, it will be relevant for future work to assess the cooperative role of DHPS and SLC3A2 in fibronectin/PEAK1-dependent switching of TGFβ signaling outcomes from predominantly Smad2/3-dependent tumor suppressive to non-canonical MAPK-dependent invasion/metastasis promoting.The other primary beta integrin subunit to mediate fibronectin signaling is integrin beta 3 (ITGB3) [52]."
reach
"We believe that this peculiar localization of endocan would be linked with a participation in the assembly, disassembly, and signaling of focal adhesions, in which integrin-beta 3 clustering induced by FN and activation of adaptor proteins, including focal adhesion kinase (FAK) and paxillin that interact with cytoskeletal proteins such as microtubules and actin microfilaments, are required."