IndraLab

Statements

KIT binds CD63. 6 / 8
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"Rather, the kinetics of SCF binding to c-Kit were altered when c-Kit associated with CD63."
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"To investigate the role of CD63 in determining the speed of cKIT endocytoses and therefore, the variegation of its signaling, the physical association between CD63 and cKIT in cells from AB, CB, and PV was investigated by IPs (Figures 6A,B)."
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"These results indicate that in erythroid cells CD63 binds cKIT phosphorylated at Y721."
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"In PV, JAK2V617F interferes with the endocytosis signaling of CD63 retaining the CD63/cKIT complex on the cell surface, while in CB the lower levels of CD63 expression delay endocytosis of the receptor."
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"CKIT and CD63 Are Constitutively Associated in PV."
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"These results indicate that in erythroid cells CD63 binds cKIT phosphorylated at Y721."
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