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USP3 inhibits ubiquitination TRAF6. 1 / 1
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"Moreover , USP3 can reverse the ubiquitination of TRAF6 ( tumor necrosis factor-receptor-associated factor 6 ) , which intermediates the signals from inflammatory cytokines to NF-kappaB activation , thus blocking IL-1beta-induced chondrocyte apoptosis [ 27 ] ."