IndraLab

Statements

USP38 activates Atrial Fibrillation. 7 / 7
| 7
reach
"In conclusion, USP38 promotes inflammatory AF induced by pressure overload."
38288617
reach
"Conversely, USP38 overexpression further increased susceptibility to AF by exacerbating atrial structural and electrical remodelling."
38288617
reach
"Overall, our study indicates that USP38 promotes pressure overload-induced AF through targeting NF-kappaB/NLRP3-mediated inflammatory responses."
38288617
reach
"Ubiquitin-specific protease 38 (USP38) was upregulated in the left atrium after aortic banding surgery.Cardiac-specific knockout of USP38 attenuated the atrial dilation and fibrosis and reduced the vulnerability of atrial fibrillation (AF) induced by pressure overload.Cardiac-specific overexpression of USP38 aggravated the atrial structural and electrical remodelling induced by pressure overload.Ubiquitin-specific protease 38 promoted atrial inflammation by interacting with and deubiquitinating nuclear factor-kappa B.Targeting USP38 may be an effective treatment for AF induced by pressure overload."
38288617
reach
"Ubiquitin-specific protease 38 (USP38) was upregulated in the left atrium after aortic banding surgery.Cardiac-specific knockout of USP38 attenuated the atrial dilation and fibrosis and reduced the vulnerability of atrial fibrillation (AF) induced by pressure overload.Cardiac-specific overexpression of USP38 aggravated the atrial structural and electrical remodelling induced by pressure overload.Ubiquitin-specific protease 38 promoted atrial inflammation by interacting with and deubiquitinating nuclear factor-kappa B.Targeting USP38 may be an effective treatment for AF induced by pressure overload."
38288617
reach
"It was found that overexpression of USP38 increased vulnerability to AF in diabetic mice."
39920799
reach
"USP38 overexpression increased susceptibility to AF, accompanied by aberrant expression of calcium-handling protein, heightened iron load and oxidation stress in diabetic mice."
39173894