IndraLab

Statements

Levobupivacaine inhibits KCNH2. 2 / 2
| 2
reach
"The amide local anaesthetics bupivacaine, levobupivacaine and ropivacaine inhibited HERG channels at toxicologically relevant concentrations, with IC (50) values of 20 (SEM 2) micro M (n = 29), 10 (1) micro M (n = 40) and 20 (2) micro M (n = 49), respectively."
14665560
reach
"As levobupivacaine in the blood blocks cardiac sodium, calcium as well as HERG potassium channels, it can directly prolong the QTc interval (Graf et al., 1997; Gonzalez et al., 2002)."
37274100