IndraLab

Statements

USP22 activates EGFR. 8 / 8
| 8
reach
"We show here that overexpression of USP22 prevents EGFR down-regulation, while shRNA mediated silencing of USP22 enhances EGFR degradation."
29981430
reach
"Thus, stabilization and activation of EGFR by USP22 are likely to be important factors in the mechanism underlying the oncogenicity and drug-resistance in EGFR-mutant lung ADCs."
29981430
reach
"Our study suggests that USP22 antagonizes EGFR degradation and amplifies EGFR signaling activity to promote EGFR-TKIs resistance in EGFR mutated lung ADCs."
29981430
reach
"USP22 can protect epidermal growth factor (EGR) receptor (EGFR) on late endosomes from degradation by deubiquitination and enhance EGFR recirculation after EGF stimulation, thereby activating multiple[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
33989708
reach
"Cancer cells express proteins such as sortilin, tribbles homolog 3 protein (TRIB3), and ubiquitin specific peptidase 22 (USP22), which suppress EGFR degradation via EGFR stabilization, and their knockdown inhibits cancer cells [39–41]."
38745775
reach
"Of note, more EGFR colocalized with Rab11 in the PC9 cells with overexpression of USP22 than the control cells, which confirms that USP22 enhances EGFR recycling."
29981430
reach
"However, our finding on prevention of endocytosis mediated EGFR degradation by USP22 reveals one vital aspect of USP22 's diverse functions."
29981430
reach
"Ubiquitin-specific protease 22 (USP22) has been shown to prevent ubiquitination-mediated EGFR degradation and activate multiple EGFR downstream signaling pathways, thus conferring resistance to EGFR-TKIs in mutant lung adenocarcinoma cells [169]."
36694209