IndraLab

Statements

USP22 activates EGFR. 5 / 5
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"Of note, more EGFR colocalized with Rab11 in the PC9 cells with overexpression of USP22 than the control cells, which confirms that USP22 enhances EGFR recycling."
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"However, our finding on prevention of endocytosis mediated EGFR degradation by USP22 reveals one vital aspect of USP22 's diverse functions."
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"Our study suggests that USP22 antagonizes EGFR degradation and amplifies EGFR signaling activity to promote EGFR-TKIs resistance in EGFR mutated lung ADCs."
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"Thus, stabilization and activation of EGFR by USP22 are likely to be important factors in the mechanism underlying the oncogenicity and drug-resistance in EGFR-mutant lung ADCs."
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"We show here that overexpression of USP22 prevents EGFR down-regulation, while shRNA mediated silencing of USP22 enhances EGFR degradation."
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