IndraLab

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KCNMA1 activates cell population proliferation. 15 / 16
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"The BK channel openers NS1619 or tamoxifen significantly induced apoptosis reducing cell viability in cells expressing the combination of the hslo + beta 1 subunits under hyperglycemia conditions suggesting that cloned BK channel directly regulates apoptosis and proliferation of HEK293 cell."
23874973
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"In addition, at cellular levels stimulation of KCNMA1 channels enhances proliferation of human pre-adipocytes in vitro [XREF_BIBR]."
21708048
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"Inhibiting KCa1.1 on FLS reduces the ability of FLS to stimulate T EM cell proliferation and migration, and inhibiting Kv1.3 on T EM cells reduces T EM cells ' ability to enhance FLS expression of KCa1.1 and major histocompatibility complex class II protein, as well as stimulates their invasion."
30612588
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"In light of our observations that TRAM-34 and Paxilline inhibited KCa3.1 and KCa1.1 currents, respectively, we tested whether pharmacological inhibition of KCa1.1 and KCa3.1 channels decreases ccRCC cell proliferation in vitro (XREF_SUPPLEMENTARY)."
25848765
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"KCa1.1 block enhances myoblast proliferation."
27763639
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"Blocking KCa1.1 channels expressed by RA-FLS with paxilline or TEA inhibits their proliferation and production of pro-MMP-2."
25252152
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"Blocking KCa1.1 in normal myoblasts induced an increase in proliferation, similar to that observed with DM1 myoblasts, whereas overexpression of full-length KCa1.1 alpha in DM1 myoblasts reduced their proliferation to levels observed in normal myoblasts."
27763639
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"KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer."
17146446
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"Our findings show that SLO and EX indeed are able to increase lymphocyte proliferation, but their association did not induce further stimulation in the adaptive immune response and also did not modify innate immunity."
20033704
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"By activating β1 integrin, SLO recruits nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2), produces reactive oxygen species (ROS), and induces ineffective LC3-related phagocytosis (LAP), leading to insufficient acidification to evade host autophagic clearance and promoting the proliferation of GAS (Lu et al., 2015; Cheng et al., 2019)."
35029086
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"We found that knockdown of KCNMA1 by siRNA and specific BK channel blockade by iberiotoxin inhibited cell proliferation of the prostate cancer cell line PC3, which carries an amplification of KCNMA1."
22899999
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"In vitro studies proved that knockdown of KCNMA1 inhibited cell proliferation or invasiveness in different types of cancer, such as glioblastoma, breast and prostate cancer, although this not seemed to apply to all [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
25397596
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"As previously observed, there were no CFUs of emm type 1.0 in blood at 24 h, but a significant 4 Log increase in CFUs was observed when emm type 1.0 was infected with the supernatant swap dose, clearly suggesting that the high concentration of SLO present in emm type 32.2 supernatant was enabling proliferation and retention of emm type 1.0 in blood as compared to its normal condition of being cleared from blood (Fig. 5D)."
34561464
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"MTT and flow cytometry assays showed that TEA, Tet, or iberiotoxin (Ibtx), a selective BK channel blocker, inhibited HeLa and A2780 cell proliferation in a dose dependent manner with G1 phase arrest."
17624594
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"Steady-state antigen cross presentation by DCs in secondary lymphoid organs (SLO) has been shown to induce the abortive proliferation and deletion of CD8 + T cells bearing cognate TCRs in experimental systems using engineered model tissue antigens XREF_BIBR, XREF_BIBR, XREF_BIBR, supporting the notion that DC mediated peripheral deletion is a key mechanism in the maintenance of self-tolerance."
30902900