IndraLab

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KCNMA1 activates cell population proliferation. 25 / 26
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"As previously observed, there were no CFUs of emm type 1.0 in blood at 24 h, but a significant 4 Log increase in CFUs was observed when emm type 1.0 was infected with the supernatant swap dose, clearly suggesting that the high concentration of SLO present in emm type 32.2 supernatant was enabling proliferation and retention of emm type 1.0 in blood as compared to its normal condition of being cleared from blood (Fig. 5D)."
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"KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer."
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"In light of our observations that TRAM-34 and Paxilline inhibited KCa3.1 and KCa1.1 currents, respectively, we tested whether pharmacological inhibition of KCa1.1 and KCa3.1 channels decreases ccRCC cell proliferation in vitro (XREF_SUPPLEMENTARY)."
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"In vitro studies proved that knockdown of KCNMA1 inhibited cell proliferation or invasiveness in different types of cancer, such as glioblastoma, breast and prostate cancer, although this not seemed to apply to all [XREF_BIBR, XREF_BIBR, XREF_BIBR]."
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"Penitrem A, a selective BK channel blocker, was demonstrated to reduce breast cancer cell proliferation and invasion through the Wnt/beta-catenin pathway [114,120,121]."
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"Steady-state antigen cross presentation by DCs in secondary lymphoid organs (SLO) has been shown to induce the abortive proliferation and deletion of CD8 + T cells bearing cognate TCRs in experimental systems using engineered model tissue antigens XREF_BIBR, XREF_BIBR, XREF_BIBR, supporting the notion that DC mediated peripheral deletion is a key mechanism in the maintenance of self-tolerance."
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"Such beneficial effects of BK channel facilitation are consistent with the general recognition that BK channel activity supports cell survival and proliferation of various neural and non-neural cells [MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"KCNMA1 gene amplification promotes tumor cell proliferation in human prostate cancer."
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"KCa1.1 block enhances myoblast proliferation."
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"Blocking KCa1.1 in normal myoblasts induced an increase in proliferation, similar to that observed with DM1 myoblasts, whereas overexpression of full-length KCa1.1 alpha in DM1 myoblasts reduced their proliferation to levels observed in normal myoblasts."
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"It was found that the KCa1.1 channel regulates the FLS-mediated activation and proliferation of effector memory T (T ) cells."
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"By activating β1 integrin, SLO recruits nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2), produces reactive oxygen species (ROS), and induces ineffective LC3-related phagocytosis (LAP), leading to insufficient acidification to evade host autophagic clearance and promoting the proliferation of GAS (Lu et al., 2015; Cheng et al., 2019)."
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"MTT and flow cytometry assays showed that TEA, Tet, or iberiotoxin (Ibtx), a selective BK channel blocker, inhibited HeLa and A2780 cell proliferation in a dose dependent manner with G1 phase arrest."
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"Inhibiting KCa1.1 on FLS reduces the ability of FLS to stimulate T EM cell proliferation and migration, and inhibiting Kv1.3 on T EM cells reduces T EM cells ' ability to enhance FLS expression of KCa1.1 and major histocompatibility complex class II protein, as well as stimulates their invasion."
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"In addition, at cellular levels stimulation of KCNMA1 channels enhances proliferation of human pre-adipocytes in vitro [XREF_BIBR]."
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"Blocking BK channel activity with paxilline or shRNA significantly inhibited proliferation in human MSCs [135]."
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"Hu et al. demonstrated that blocking of the KCa1.1 channel with tetraethylammonium (TEA) disturbs the calcium homeostasis and inhibits the proliferation, invasion, and production of VEGF, IL-8, and pro-MMP 2 by RA FLs."
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"The BK channel openers NS1619 or tamoxifen significantly induced apoptosis reducing cell viability in cells expressing the combination of the hslo + beta 1 subunits under hyperglycemia conditions suggesting that cloned BK channel directly regulates apoptosis and proliferation of HEK293 cell."
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"The expression of KCNMA1 , contributes to high cellular proliferation and increased invasiveness of melanoma cell lines [112] ."
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"Elevated Slo expression promotes dRaf GOF glioma cell proliferation."
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"Our findings show that SLO and EX indeed are able to increase lymphocyte proliferation, but their association did not induce further stimulation in the adaptive immune response and also did not modify innate immunity."
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"We found that knockdown of KCNMA1 by siRNA and specific BK channel blockade by iberiotoxin inhibited cell proliferation of the prostate cancer cell line PC3, which carries an amplification of KCNMA1."
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"Blocking KCa1.1 channels expressed by RA-FLS with paxilline or TEA inhibits their proliferation and production of pro-MMP-2."
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"KCNMA1 can augment the proliferation of prostate cancer cells [35], and the above studies indicate that most genes are closely related to cancer."
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"Unsurprisingly, blockade of the BK channel with paxilline disrupts Ca homeostasis and prevents RA-FLS proliferation and invasion by inhibiting cytokine and MMP production."
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