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Lipopolysaccharide activates CACNA1C. 2 / 2
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"IL-1beta knockout in macrophages restored the LPS stimulated macrophage induced inhibition of QKI and CACNA1C (alpha1C subunit of L-type calcium channel) in atrial myocytes."
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"Overall, it might be worth examining whether LPS-induced activation of somatic ATP and cytokine release occurs through STIM1 downregulation-mediated activation of Cav1.2, and increase SGC Ca signaling by activating the upregulated P2X7 in the sympathetic ganglia.In conclusion, our findings offer foundational insights into the major mechanism of Ca signaling in SGCs, comparing them with the principal neurons in the sympathetic ganglia."
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