IndraLab

Statements

1,2-di-O-arachidonoyl-sn-glycero-3-phosphocholine inhibits KCNMA1. 4 / 4
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"We show that a compromise in either the DAPC or ISLO-1 abrogates normal SLO-1 channel localization and results in excessive muscle contraction."
20019812
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"A defect in the DAPC disrupts coupling of the BK channel to L-type Ca 2+ channels, causing a prolonged muscle activation and elevated calcium ions."
20019812
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"Notably, we observed that mutations in DAPC genes that disrupt SLO-1 localization do not convert the phenotype of egl-19 gain-of-function mutants to the loss-of-function phenotype (unpublished data, HK)."
20019812
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"We show that a defect in either the DAPC or ISLO-1 disrupts normal SLO-1 localization in muscle."
20019812