IndraLab

Statements

USP33 activates TGFBR2. 6 / 6
| 6
reach
"The IF assay showed that after the overexpression of USP33, the colocalization of TGFBR2 with lysosome was impaired, meanwhile USP33 overexpression promoted the accumulation of TGFBR2 in cell membrane (Fig. 5K)."
37322017
reach
"Moreover, our data showed that USP33 promoted the recycling of TGFBR2 to cell membrane in PC cells during its internalization (Fig. S2)."
37322017
reach
"In conclusion, our study suggested that USP33 prevented the degradation of TGFBR2 by lysosome by promote its recycling by the recycling endosome."
37322017
reach
"Mechanistically, USP33 interacted with TGFBR2 through DUSP1 domain of USP33, moreover, USP33 enhanced the protein stability of TGFBR2 by removing the K63-linked ubiquitin chains on TGFBR2."
37322017
reach
"Mechanistically, USP33 deubiquitinated and stabilized the TGFBR2 protein in PC cells and therefore enhanced the signaling of TGF-β pathway, USP33 removed the K63-linked ubiquitin conjugates from TGFBR2 and prevented its degradation by lysosome, meanwhile, USP33 promoted the recycling of TGFBR2 to cell membrane and eventually enhanced the signaling in TGF-β pathway."
37322017
reach
"USP33 promoted the recycling of TGFBR2."
37322017