IndraLab

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USP38 activates TBK1. 3 / 3

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"Meanwhile, we found that knockdown of USP38 accelerated the degradation of p-TBK1 induced by CHX, while USP38 overexpression delayed its degradation (Figure 8I and 8J)."

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"USP38 prevents the proteasomal degradation of p-TBK1."

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"Mechanistically, USP38 prevents the proteasomal degradation of p-TBK1, thus activating the downstream Akt-GSK3β/mTOR signaling pathways."

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IndraLab

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USP38 activates TBK1. 3 / 3

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