IndraLab

Statements

Phorbol 13-acetate 12-myristate inhibits FOS. 6 / 6
| 6
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"Down-regulation of PKC by overnight pre-treatment with 12-O-tetradecanoylphorbol 13-acetate (TPA) blocked only the phorbol ester stimulated c-fos accumulation while no effect was observed in the carbachol induced response."
9037533
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"In addition, the cotreatment with RA reduced (5 micromol/L, P < 0.05; 10 and 20 micromol/L, P < 0.01) TPA induced transcription from a control activator protein-1 (AP-1) promoter-luciferase construct and repressed binding of the AP-1 factors c-Jun (10 micromol/L; P < 0.01) and c-Fos (10 micromol/L; P < 0.05) to COX-2 promoter oligonucleotides harboring a cAMP response element (CRE)."
18936204
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"In addition, 5 '-NIO exerted strong inhibitory effects on the EGF- or TPA induced c-fos or c-jun transcriptional activity, and thereby inhibited the associated activator protein-1 (AP-1) transactivation activity induced by EGF or TPA."
21400615
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"In colon cancer, HT-29 cells in vitro, rosmarinic acid, a constituent of rosemary, reduced 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced COX-2 promoter activity (p <.05) and protein levels (p <.05), reduced TPA induced transcription from a control activator protein-1 (AP-1) promoter-luciferase construct, and repressed binding of the AP-1 factors c-Jun (p <.01) and c-Fos (p <.05) to COX2 promoter oligonucleotides harboring a cAMP response element (CRE) (Scheckel et al., 2008)."
22432564
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"In the absence of added TPA, c-Fos activated both Fbxo10 promoters, whereas c-Jun antagonized c-Fos activation of these Fbxo10 reporters (Figure 4A–C)."
24008983
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"Pretreatment with DHA resulted in significant inhibition of TPA induced activation of c-fos and c-jun (XREF_FIG)."
27654969