IndraLab

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Hydroxychloroquine inhibits cell population proliferation. 49 / 49
| 3 46
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"HCQ could inhibit CD4+T cell proliferation at 40 and 60 µM (Figures 3D, E)."
35401507
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"HCQ (40 and 60 µM) inhibited the proliferation of CD4+T cells obviously with statistical difference (N=5)."
35401507
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"In vitro, HCQ inhibited Th17 cell proliferation and differentiation, as well as IL-17 production."
29545450
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"HCQ can decrease the proliferation of T cells via inhibiting the production of IL-2, ultimately affecting the body's anti-viral immunity."
32415419
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"Since HCQ inhibits the proliferation of T cells, it may not bring good news for COVID-19 patients who are in the ICU."
32415419
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"Conclusion: HCQ could inhibit cell proliferation and induce apoptosis in cholangiocarcinoma by triggering ROS accumulation via autophagy inhibition, which makes HCQ a potential antitumor drug candidate for cholangiocarcinoma treatment."
34568426
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"In addition, HCQ inhibited growth of cholangiocarcinoma cell line xenograft tumors.Conclusion: HCQ could inhibit cell proliferation and induce apoptosis in cholangiocarcinoma by triggering ROS accumulation via autophagy inhibition, which makes HCQ a potential antitumor drug candidate for cholangiocarcinoma treatment."
34568426
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"To the best of our knowledge, the current study provides the first evidence that HCQ inhibits the autophagy of cervical cancer SiHa cells and then prevents their proliferation by promoting apoptosis."
24944668
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"Our results showed that HCQ treatment suppressed breast cancer cell proliferation and migration in especially SUM-190 cells, which was most sensitive."
31488317
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"Chloroquine and its less toxic derivative, hydroxychloroquine, are known to inhibit SARS-CoV-2 proliferation through various pathways (XREF_FIG)."
33572274
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"Since chloroquine (CQ) and hydroxychloroquine (HCQ) can inhibit the invasion and proliferation of SARS-CoV-2 in cultured cells, the repurposing of these antimalarial drugs was considered a promising strategy for treatment and prevention of COVID-19."
33693723
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"It is not clear whether this is related to the fact that anti-malarial drugs, such as hydroxychloroquine, have been used as a secondary treatment for RA for many years 22, and it has been suggested that hydroxychloroquine interferes with Toll like receptor signaling 23 to reduce immune cell activation and proliferation, although its exact mechanism of action in ameliorating RA is still not well understood."
28491277
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"These results show that CQ and HCQ inhibited carotid artery ligation induced VSMC proliferation."
32821717
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"RAPA and HCQ inhibited the proliferation of RPMI8226 in a concentration- and time dependent manner, and increased the apoptosis."
29950226
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"HCQ preadministration suppressed the proliferation of PTECs by arresting cells in G1/S phase and upregulated the expression of cell cycle inhibitors."
| PMC
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"By decreasing miR-21 expression, HCQ may contribute to decreased mesangial cell proliferation and reduced inflammatory cell infiltration through decreased production of IL-6."
24121037
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"The results demonstrated that CQ and HCQ inhibit cell proliferation and cell cycle progression in VSMCs via the AMPK dependent signaling pathway."
32821717
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"The results showed that CQ and HCQ inhibited the proliferation of multiple human bladder cell lines (including RT4, 5637, and T24) in a time- and dose dependent fashion, especially in advanced bladder cancer cell lines (5637 and T24) compared to immortalized uroepithelial cells (SV-Huc-1) or other reference cancer cell lines (PC3 and MCF-7)."
28433067
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"HCQ preadministration suppressed the proliferation of PTECs by arresting cells in G1/S phase and upregulated the expression of cell cycle inhibitors."
34980245
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"Previously, Ramser et al found that HCQ significantly reduces the metabolic activity and suppresses the cell proliferation of human dermal fibroblasts."
24944668
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"Chloroquine and hydroxychloroquine inhibit IL-2 production and then T cell proliferation and differentiation."
32417904
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"Since HCQ inhibits the proliferation of T cells, it may not bring good news for COVID-19 patients who are in the ICU."
32415419
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"The patient's cultured fibroblasts were incubated with selected drugs, and cell proliferation was inhibited by hydroxychloroquine."
31520587
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"HCQ and AZM can suppress SARS-CoV-2 proliferation in vitro and may slow the cell-to-cell spread of the virus; a large case series evaluating this combination in early-stage patients reported an impressively low mortality rate."
| PMC
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"In brief, long-term HCQ treatment aggravated PTEC apoptosis and suppressed PTEC proliferation by promoting G1/S cycle arrest, resulting in delayed renal recovery from AKI [37]."
| PMC
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"HCQ inhibits SiHa cell proliferation by inducing apoptosis."
24944668
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"HCQ decreased IRBP 1-20 -specific T cell responses and proliferation of CD4 + T cells in vitro ."
35401507
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"Moreover, HCQ blocks T-cell and monocyte proliferation, inhibits TLR signaling, and downregulates cytokine production including TNF-alpha, IL-17, IL-6, IFNalpha, and IFNgamma [XREF_BIBR]."
29670462
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"In conclusion, we found that CQ and HCQ activated AMPK and inhibited PDGF induced VSMC proliferation."
32821717
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"HCQ interferes with antigen processing and presentation 14, decreases production of IL-1, IL-6, and TNF-alpha XREF_BIBR, XREF_BIBR, and decreases proliferation and cytotoxicity resulting from allorecognition."
21689773
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"In this issue, Ramser et al. show that HCQ inhibits proliferation of HDFs and induces autophagy."
19749781
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"The number of cell colonies that survived due to long-term treatment with HCQ or Torin-1 was examined by Image J software and demonstrated that HCQ inhibits HCC proliferation and inhibits HCC growth in long-term cultures, whereas Torin 1 treatment promotes HCC survival."
28402954
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"Moreover, HCQ inhibits T cell activation, proliferation, and cytokine production by inhibiting intracellular calcium and mobilization and subsequent NFAT signalling [XREF_BIBR, XREF_BIBR] and apoptosis in CD45RO+ memory and effector T cells by inhibiting autophagy [XREF_BIBR]."
33763494
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"As the majority of previous studies focused on the innate immunity, only a few in vitro studies showed that HCQ could reduce the activation, proliferation and differentiation of T cells (11–13)."
35401507
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"It was also reported that HCQ effectively inhibited the proliferation of fibroblasts, suppressed metabolic activities in fibrotic skin diseases and inhibited extracellular signalling regulated kinase ERK1/2 activation in human dermal fibroblasts 7."
28878315
eidos
"The patient 's cultured fibroblasts were incubated with selected drugs , and cell proliferation was inhibited by hydroxychloroquine ."
31520587
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"Hydroxychloroquine, also an autophagy inhibitor, reduced the metabolic activity and suppressed cell proliferation of human fibroblasts XREF_BIBR)."
32281584
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"HCQ and AZM can suppress SARS-CoV-2 proliferation in vitro and may slow the cell-to-cell spread of the virus; a large case series evaluating this combination in early-stage patients reported an impressively low mortality rate."
32650197
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"These results indicate that CQ or HCQ inhibit TGF-beta1-induced VSMCs proliferation via Smad3 and AMPK pathways."
32821717
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"HCQ inhibited cell proliferation and induced apoptosis and cycle arrest in vitro by increasing ROS accumulation, which was involved in autophagy inhibition."
34568426
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"We have demonstrated that HCQ causes a dose dependent reduction of the cytotoxicity, proliferation, and TNF alpha production resulting from allorecognition in mixed lymphocyte culture (MLC)."
8807116
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"HCQ triggers apoptosis and suppresses cell proliferation."
26134285
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"Rapamycin can inhibit the proliferation, induce apoptosis and autophagy of RPMI 8226, the hydroxychloroquine can inhibit autophagy and proliferation of RPMI 8226, and induce apoptosis, the 3-MA can inhibit autophagy of RPMI 8226, but hardly has any effects on proliferation and apoptosis of RPMI 8226 cells."
29950226
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"Therefore, promoting senescence and impairing the autophagy-lysosomal pathway may be an important mechanism by which HCQ increases apoptosis and suppresses proliferation in PTECs when AKI is complicated by LN."
| PMC
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"Figure 3: Hydroxychloroquine (HCQ) suppresses the differentiation and proliferation of T cells."
35401507
eidos
"HCQ inhibited cell proliferation and induced apoptosis and cycle arrest in vitro by increasing ROS accumulation , which was involved in autophagy inhibition ."
34568426
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"We next investigated whether HCQ preadministration suppressed PTEC proliferation via arresting cell cycle progression."
| PMC
eidos
"Conclusion : HCQ could inhibit cell proliferation and induce apoptosis in cholangiocarcinoma by triggering ROS accumulation via autophagy inhibition , which makes HCQ a potential antitumor drug candidate for cholangiocarcinoma treatment ."
34568426
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"In myeloma PCs, although bortezomib and HCQ alone inhibited proliferation compared to control cells (53.7 ± 7.06% and 35.54 ± 3.63% respectively), combination treatment caused a much stronger inhibition compared with control cells and with treatment with HCQ alone (up to 82.53 ± 6.34%; p = 0.0004; Figure 6A)."
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