IndraLab
Statements
|
1
70
reach
"Therefore, we hypothesized that ART might have the same excellent effects as HCQ in alleviating kidney injury and reducing proteinuria by inhibiting the activation and proliferation of B cells, inhibiting the generation of Gd-IgA1, and inhibiting inflammatory cytokines.However, although a large amount of experimental evidence has been accumulated, there is still a lack of randomized controlled clinical trials to verify the potential effect of ART in the treatment of IgA nephropathy."
reach
"A study suggested that treatment with bortezomib and hydroxychloroquine prevents the pro-angiogenic effect of bortezomib, the proliferation of a small residual tumor PC clone, and thus the relapse.8A myeloma microenvironment can enhance myeloma cell growth and survival and contribute to drug resistance."
reach
"LEF alone dose-dependently inhibited proliferation of T and B cells, production of cytokines CXCL13, IFN-alpha and IFN-gamma and production of IgG and IgM.3.2 Suboptimal concentrations of the HCQ and LEF combination additively inhibit T cell proliferation, B cell proliferation and CXCL13 production (in pSS patients) and inhibit IFN-alpha and immunoglobulinsNext, we investigated the effects of the combination of csDMARDs in this culture system."
reach
"To understand how HCQ or BC001 inhibits proliferation and promotes cell death in BGC823 cells, we treated BGC823 cells with 5 µg/ml HCQ or 20 µg/ml BC001 for 48 h and performed global profiling of the transcriptome of HCQ or BC001-treated cells via RNA-Seq to identify the candidate genes."
reach
"Rapamycin can inhibit the proliferation, induce apoptosis and autophagy of RPMI 8226, the hydroxychloroquine can inhibit autophagy and proliferation of RPMI 8226, and induce apoptosis, the 3-MA can inhibit autophagy of RPMI 8226, but hardly has any effects on proliferation and apoptosis of RPMI 8226 cells."
reach
"In experiments with rodents and PBMC isolated from SLE and HIV patients, HCQ attenuated Th17 differentiation, proliferation, and production of IL-17 while promoting the immunosuppressive effect of Tregs (Piconi et al., 2011; An et al., 2017; Yang et al., 2018; Kowatsch et al., 2023)."
reach
"A study conducted by Lernia et al demonstrated that the combination of bortezomib and hydroxychloroquine with anti-angiogenic drugs effectively suppresses the proliferation of residual tumor PC clones by neutralizing the pro-angiogenic impact of bortezomib, consequently impeding relapse."
reach
"Moreover, pharmacological activator of autophagy RAP treatment significantly decreased cell proliferation and enhanced cell apoptosis compared with shPHLPP transfection alone in U266 cells (Figure 5A and B); the autophagy inhibitor hydroxychloroquine (HCQ) treatment dramatically promoted cell proliferation and reduced cell apoptosis compared with PHLPP transfection alone in U266-R cells (Figure 5C and D)."
reach
"Interestingly, the multilayered proliferation of fibroblastic/spindle cells on tibial trabecular surfaces in mice treated with multiple daily doses of PTH was prevented by 156 mM/kg HCQ and 31.25 mM/kg HABP-HCQ, and the mice had only a single layer of osteoblastic cells on trabecular surfaces (Fig. 3C)."
reach
"Aspirin inhibits the proliferation, invasion, and metastasis of residual VX2 tumors through an anti-inflammatory effect.141 RFA and the antimalarials, chloroquine (CQ)/hydroxychloroquine (HCQ), inhibit the autophagy, proliferation, and stemness of tumor cells and promote their apoptosis.142, 143, 144 This effect can be enhanced by combining CQ and c-Met inhibitors.48 Metformin reduces the proliferation, migration, and invasion of HCC cells,145 and the expression of stem cell markers.46 All-trans retinoic acid (ATRA) eliminates tumor-initiating cells through the PI3K/AKT pathway."
reach
"Since at this concentration no inhibition of T cell proliferation, CXCL13, IFNgamma or IFNalpha production was observed HCQ seems to target B cells independent of these processes.We demonstrate that both LEF and HCQ inhibit T and B cell proliferation and production of CXCL13, IFN-alpha, IFN-gamma and immunoglobulins IgG and IgM, all of which are important contributors to pSS pathology, albeit with different potencies."
reach
"The results showed that CQ and HCQ inhibited the proliferation of multiple human bladder cell lines (including RT4, 5637, and T24) in a time- and dose dependent fashion, especially in advanced bladder cancer cell lines (5637 and T24) compared to immortalized uroepithelial cells (SV-Huc-1) or other reference cancer cell lines (PC3 and MCF-7)."
reach
"In addition, HCQ inhibited growth of cholangiocarcinoma cell line xenograft tumors.Conclusion: HCQ could inhibit cell proliferation and induce apoptosis in cholangiocarcinoma by triggering ROS accumulation via autophagy inhibition, which makes HCQ a potential antitumor drug candidate for cholangiocarcinoma treatment."
reach
"In myeloma PCs, although bortezomib and HCQ alone inhibited proliferation compared to control cells (53.7 ± 7.06% and 35.54 ± 3.63% respectively), combination treatment caused a much stronger inhibition compared with control cells and with treatment with HCQ alone (up to 82.53 ± 6.34%; p = 0.0004; Figure 6A)."
reach
"It is not clear whether this is related to the fact that anti-malarial drugs, such as hydroxychloroquine, have been used as a secondary treatment for RA for many years 22, and it has been suggested that hydroxychloroquine interferes with Toll like receptor signaling 23 to reduce immune cell activation and proliferation, although its exact mechanism of action in ameliorating RA is still not well understood."