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TNFAIP3 activates cell differentiation. 4 / 4
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"By regulating the expression of miR-125a-5p and TNFAIP3, the long non-coding RNA (lncRNA) MEG3 affects osteogenic differentiation of mesenchymal stem cells; overexpression of MEG3 and TNFAIP3 or inhibition of miR-125a-5p can suppress the osteogenic differentiation of BMSCs, offering new strategies for the treatment of ankylosing spondylitis (Liu C et al., 2023)."
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"The deficiency of TNFAIP3 in MSCs can induce immune thrombocytopenia and influence megakaryocytic differentiation through terminating the NF-kappaB pathway that suggests TNFAIP3 play a critical role in the process of MSCs alleviate s autoimmune disease [XREF_BIBR]."
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"Furthermore, knockdown of exocyst component 3 (exoc3), a negative regulator of pluripotency whose mammalian homolog Tnfaip3 promotes embryonic stem cell differentiation, causes expansion of the S/G2/M (X1) neoblast fraction ."
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"TNFAIP3 deficient DCs induced HDM specific T H 17cell differentiation through increased expression of the T H 17 instructing cytokines IL-1beta, IL-6, and IL-23, whereas HDM specific T H 2 cell differentiation was hampered by increased IL-12 and IL-6 production."
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