IndraLab

Statements

CACNA1S activates calcium(2+). 9 / 9
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"Compared with previous studies, we reported two new Ca 2+ channels, PMCA1 and CACNA1S that were related to Se deficiency and Ca 2+ leak but found that RyRs were not involved in the Se deficiency induced Ca 2+ leak."
27557522
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"docked structures of the Ca 1.1 complex (PDB: 3JBR) and RyR1, hypothesizing that domains of Cav1.1α1 would cause shifts of the β-subunit and other cytoplasmic segments of Ca 1.1 upon depolarization, which might prompt movement of the neighboring cytoplasmic RyR1, such as SPRY3 domain."
35677449
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"The low expression of ADRB1, CACNA1S, and EDNRB, which mediate the entry of ions Ca to the intracellular medium, suggests low Ca stocks in the cytoplasm, consequently, reflects in the decrease of calcium in the mitochondria [30,46]."
31973088
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"Grasset et al. reported that high expression of Cav1.1 promotes the collective migration of squamous cell carcinoma cells by increasing intracellular Ca , while Cav1.1 gene silencing by using blockers (diltiazem and verapamil) of L-type Ca channels decreases the invasive properties of tumor cells both in vitro and in vivo [39]."
35509066
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"No medication has been shown to prevent the myopathy associated with hyperPP.Hypokalemic periodic paralysisMost cases of hypoPP are caused by mutations in CACNA1S, the gene encoding the skeletal muscle voltage gated calcium channel alpha-subunit [82]."
19811036
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"Therefore, redox regulated SERCA, CACNA1S, TRPC1, and TRPC3 channels by SelW may be involved in the process of Se deficiency induced Ca 2+ leak."
27557522
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"We hypothesize that Cacna1s contributes to light adaptation by permeating calcium."
24519419
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"In skeletal muscle, depolarization of the plasma membrane (PM) causes conformational changes of the calcium channel CaV1.1, which then activate RYR1 to release calcium from the sarcoplasmic reticulum (SR)."
34766994
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"Finally, Cacna1s exon 29 exclusion enhances L-type Ca channel conductance and voltage sensitivity in mouse muscle fibers."
40016516