IndraLab

Statements

USP22 deubiquitinates FOXP3. 3 / 3
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"The results revealed that USP22 can promote FoxP3 deubiquitination and stabilization, which is counteracted by the E3 ligase ring finger protein 20 (Rnf20)."
38715050
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"Similarly, USP21, USP22, and USP44 also deubiquitinate Foxp3, preventing its degradation (195–199)."
38449875
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"Loss of Usp22 in Treg reduces Foxp3 transcript levels, increases FOXP3 ubiquitination and degradation, and reduces suppressive activity in vivo in mice."
33717052