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USP2 activates Neoplasms. 11 / 11
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"Previously, USP2 was revealed to enhance tumor migration and invasion by increasing MMP-2 activity in metastatic triple-negative breast cancer (101)."
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"We found that USP2 knockout significantly suppressed tumor growth, as indicated by the smaller tumor volumes and weights in the knockout groups compared with the control group (Fig. 5E–G)."
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"These data indicate that a combination of USP2 inhibition and PD-1/PD-L1 blockade potently suppresses tumor growth in vivo, and that the contribution of USP2 inhibition to this effect is dependent on the tumor cell autonomous activity of p53."
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"As illustrated in Fig. 6A-C, the combination of USP2 overexpression and DDP treatment promoted tumor regression, evidenced by a significant reduction in tumor volume and notable decrease in weight."
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"USP2 promotes tumor immune evasion via deubiquitination and stabilization of PD-L1."
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"Pharmacological USP2 inhibition inhibits tumor progression in breast cancer and sensitizes tumor cells to chemotherapy.As well as the canonical EMT-associated markers discussed previously, matrix meta[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The combination of USP2 inhibition and the PD-1/PD-L1 immune checkpoint blockade completely suppresses tumor growth with no obvious toxicity."
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"For example, USP2 and USP7 modulate p53 and MDM2, impacting cell survival and tumor development, while USP22 stabilizes c-Myc, driving cancer proliferation and metastasis [9–13]."
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"Indeed, USP2 inhibition alone partially induces tumor growth suppression but more strikingly, the combination of USP2 inhibition and PD-1/PD-L1 blockade promote vigorous tumor regression and long-term survival of all tumor-bearing mice."
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"Moreover, although a small-molecule inhibitor of USP2 alone can partially suppress the in vivo growth of p53-wild-type mammary tumor xenografts, more strikingly, USP2 inhibition and PD-1/PD-L1 blockade in combination promote vigorous tumor regression and long-term survival of all tumor-bearing mice."
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"As a result, development of an inhibitor for USP2 could suppress tumor progression."
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