IndraLab

Statements

P5091 inhibits Multiple Myeloma. 7 / 7
| 7
reach
"P5091 inhibits human MM cell growth in vivo and prolongs survival in the MM.1 S MM xenograft mouse model."
22975377
reach
"For instance, the USP7 inhibitor P5091 in combination with lenalidomide, HDAC inhibitor SAHA, or dexamethasone triggers synergistic antitumor activity in multiple myeloma [ 133 ]."
38262120
reach
"One such inhibitor, P5091, is highly selective against USP7 and has been shown to induce apoptotic cell death in therapy resistant multiple myeloma cells ."
34660907
reach
"The USP7 inhibitor P5091 has been reported to induce apoptosis of multiple myeloma (MM) cells, and synergistic anti-MM effects can be exerted by multiple drugs."
32002017
reach
"P5091 inhibits USP7 deubiquitylating activity, without blocking proteasome activity, in MM cells."
22975377
reach
"P5091 blocks the USP7 activity in MM at the IC 50 of P5091 for these cells (XREF_FIG and data not shown)."
22975377
reach
"P22077 and P5091, two HAUSP inhibitors discovered by high-throughput screens, were demonstrated to inhibit neuroblastoma or multiple myeloma growth in vivo, respectively (Chauhan et al., 2012; Fan et al., 2013)."
31282934