IndraLab

Statements

KCNH2 inhibits ERG. 2 / 2
| 2
reach
"Using cell biology and electrophysiologic techniques, we found that hypoxic culture of hERG expressing human embryonic kidney (HEK) cells and neonatal rat cardiomyocytes reduced hERG current / I Kr and mature ERG channel expression with a concomitant increase in calpain expression."
28784631
reach
"Harley et al. (2016), demonstrated that selective disruption of the ERG1 PAS domain increased ERG currents and shortened the action potential duration in human cardiomyocytes, suggesting that the ERG PAS domain could work as an alternative target to enhance ERG current amplitude."
35600076